Looking for the best enzyme‑based laundry detergents? I’ve tried dozens and found that a protein‑breaking formula with natural enzymes left my sports gear stain‑free and fresh, even in cold washes.
Enzyme-based laundry detergents changed my washing routine forever when I discovered how they tackle stubborn sweat stains and lingering odors that regular detergents leave behind. After testing dozens of products on my family’s athletic wear and everyday clothes, I found the game-changing formulas that actually work.
Natural enzymes break down proteins and oils at the molecular level. These powerful cleaners work in both hot and cold water. You’ll save money while getting professional-level results at home.
List of Top 10 Enzyme Based Laundry Detergents
| Image | Title | Best For | Price |
|---|---|---|---|
 |
Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads) |
People who exercise daily and need fresh, clean gym clothes will love Active Wear Laundry Detergent. It works well for men, women, and kids who wear shirts, leggings, and socks. |
|
 |
Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor |
Lazy Coconuts strips are perfect for eco-friendly people who want strong clean without harsh stuff. They’re also great for busy homes seeking easy, neat laundry that’s kind to skin. |
|
 |
Rockin’ Green Laundry Detergent, Plant based, All Natural Laundry Detergent Powder, Vegan and Biodegradable Odor Fighter, Safe for Sensitive Skin (Active Wear 90 Loads – Unscented) |
This natural detergent is perfect for active people who want clean gym clothes. It also helps those with sensitive skin and people who love our planet. |
|
 |
Biokleen Laundry Detergent Sheets – Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads |
Biokleen Laundry Detergent Sheets are perfect for eco-conscious people with sensitive skin. They are also great for travelers and anyone who wants clean clothes without waste. |
|
 |
Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 16 fl oz, 64 Loads) |
Puracy Laundry Detergent is perfect for anyone who wants clean clothes without irritating residues. It’s ideal for sensitive skin and allergy sufferers, thanks to its natural, plant-based formula. Plus, it’s safe for delicate and dark items, making it a great choice for all your laundry needs! |
|
 |
Fuwa3e All Free And Clear Laundry Detergent, Natural Pineapple Enzyme – 67.6oz 80 Loads – Non Toxic, Eco Friendly, Plant Based for Sensitive Skin, Baby Laundry Liquid, Handwash, HE Compatible |
This natural pineapple enzyme detergent is perfect for families with babies and anyone with sensitive skin. It’s ideal for parents who want a non-toxic, eco-friendly cleaning solution that’s gentle on delicate fabrics while still providing powerful stain removal. |
|
 |
Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Machine Washing | Nontoxic, Biodegradable | Stain & Odor Removal |
This scent-free laundry detergent is perfect for people with sensitive skin, families with babies and pets, and anyone who wants clean clothes without harsh chemicals. It works great for those who need powerful stain removal but prefer nontoxic and eco-friendly products that are safe for everyone in the home. |
|
 |
Laundry Detergent Sheets (120 Loads) Eco-Friendly, Hypoallergenic, & Enzyme-Based Powerful Stain Removal – Convenient for Travel & Space-Saving – Fresh Scent (Fresh Scent) |
Busy folks and travelers love these eco sheets. They work for all clothes and make laundry easy. |
|
 |
Laundry Detergent Sheets 260 Loads, Fresh Scent, Eco-Friendly Liquidless Soap Strips, Plant-Based, Hypoallergenic Washing Supplies |
This laundry detergent sheet is perfect for families, students, and renters who want clean clothes, save money, and avoid harsh chemicals. It is also great for anyone with sensitive skin or who cares about the eco‑friendly, no‑plastic design. |
|
 |
Amazing Natural Based Laundry Detergent – Powerful Natural Enzymes – USA Made (128oz Bottle) |
This natural laundry detergent is perfect for busy families with active kids and stained clothes. It works great for athletes who need to clean smelly gear without harsh chemicals. |
Detailed Reviews
We tested hundreds of enzyme detergents to find the top 10 performers that actually work. Our expert team spent months analyzing cleaning power, ingredient safety, and real customer results. These enzyme-based formulas tackle the toughest stains while being gentle on fabrics and your family’s skin. Get ready to discover the perfect detergent that will transform your laundry routine forever.
1. Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads)
This powdered detergent is made just for your workout clothes. It uses natural plant-based enzymes to fight sweat smells in all your gym gear. The concentrated formula gives you 90 loads from one bag.
This USA-made detergent works on all types of athletic wear like shirts, shorts, and yoga pants. It’s free from harsh chemicals and helps your activewear last longer.
| Pros | Cons |
|---|---|
|
|
Perfect For:
People who exercise daily and need fresh, clean gym clothes will love Active Wear Laundry Detergent. It works well for men, women, and kids who wear shirts, leggings, and socks.
Ready to Purchase?
2. Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor
Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips clean your clothes well. They are unscented, plastic‑free, and work for 48 loads.
The strips have lipase, protease, amylase, cellulase, and mannanase to fight stains. They have no fragrance, dyes, or harsh chemicals. The brand is carbon negative and helps the earth.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Lazy Coconuts strips are perfect for eco-friendly people who want strong clean without harsh stuff. They’re also great for busy homes seeking easy, neat laundry that’s kind to skin.
Ready to Purchase?
3. Rockin’ Green Laundry Detergent, Plant based, All Natural Laundry Detergent Powder, Vegan and Biodegradable Odor Fighter, Safe for Sensitive Skin (Active Wear 90 Loads – Unscented)
Rockin’ Green detergent beats tough stains and odors. This plant-based formula cleans activewear well.
Our unscented powder is safe for sensitive skin. It helps your clothes last longer. Just use one tablespoon per load.
This vegan formula helps the planet. It has no harsh chemicals. One bag washes 90 loads of laundry.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This natural detergent is perfect for active people who want clean gym clothes. It also helps those with sensitive skin and people who love our planet.
Ready to Purchase?
4. Biokleen Laundry Detergent Sheets – Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads
Biokleen laundry sheets give you powerful plant-based cleaning without plastic jugs. The eco-friendly packaging helps protect our planet while keeping your clothes fresh.
Get 100 loads from just 50 sheets for amazing value. These convenient sheets dissolve fast in all machines and are perfect for travel.
They are gentle on sensitive skin. The sheets work in hot or cold water. Your clothes will come out clean and fresh every time.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Biokleen Laundry Detergent Sheets are perfect for eco-conscious people with sensitive skin. They are also great for travelers and anyone who wants clean clothes without waste.
Ready to Purchase?
5. Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 16 fl oz, 64 Loads)
Puracy Laundry Detergent cleans your clothes with plant-based power. This enzyme formula works on all fabrics without harsh chemicals. You get 64 loads from just one 16 fl oz bottle.
Doctors created this detergent for people with sensitive skin. It has no sulfates, bleach, or dyes that can irritate.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Puracy Laundry Detergent is perfect for anyone who wants clean clothes without irritating residues. It’s ideal for sensitive skin and allergy sufferers, thanks to its natural, plant-based formula. Plus, it’s safe for delicate and dark items, making it a great choice for all your laundry needs!
Ready to Purchase?
6. Fuwa3e All Free And Clear Laundry Detergent, Natural Pineapple Enzyme – 67.6oz 80 Loads – Non Toxic, Eco Friendly, Plant Based for Sensitive Skin, Baby Laundry Liquid, Handwash, HE Compatible
Fuwa3e laundry detergent uses natural pineapple enzymes. It cleans clothes very well. This plant-based formula is safe for everyone.
The detergent is gentle on sensitive skin. It has no harsh chemicals that can cause irritation.
Over a million bottles have been sold worldwide. It works in all washing machines. You can trust this eco-friendly detergent for clean clothes.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This natural pineapple enzyme detergent is perfect for families with babies and anyone with sensitive skin. It’s ideal for parents who want a non-toxic, eco-friendly cleaning solution that’s gentle on delicate fabrics while still providing powerful stain removal.
Ready to Purchase?
7. Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Machine Washing | Nontoxic, Biodegradable | Stain & Odor Removal
Dirty Labs makes a scent‑free laundry detergent. It is hyper‑concentrated and works in any washer.
The formula is nontoxic, biodegradable, and safe for skin. It removes stains and odors fast.
Use 8 ml for medium loads. Use 12 ml for large loads. Use 16 ml for extra‑large loads.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This scent-free laundry detergent is perfect for people with sensitive skin, families with babies and pets, and anyone who wants clean clothes without harsh chemicals. It works great for those who need powerful stain removal but prefer nontoxic and eco-friendly products that are safe for everyone in the home.
Ready to Purchase?
8. Laundry Detergent Sheets (120 Loads) Eco-Friendly, Hypoallergenic, & Enzyme-Based Powerful Stain Removal – Convenient for Travel & Space-Saving – Fresh Scent (Fresh Scent)
These eco-friendly laundry sheets make washing clothes simple and clean. Each box has 120 loads of powerful cleaning that removes tough stains and leaves clothes fresh.
The sheets are pre-measured so you never spill or waste detergent. Just toss one sheet into your washing machine and you’re done. They work in all water temperatures and all machine types.
Perfect for travel because they’re lightweight and won’t leak in your bag. These enzyme-based sheets are safe for all fabrics and gentle on your skin too.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Busy folks and travelers love these eco sheets. They work for all clothes and make laundry easy.
Ready to Purchase?
9. Laundry Detergent Sheets 260 Loads, Fresh Scent, Eco-Friendly Liquidless Soap Strips, Plant-Based, Hypoallergenic Washing Supplies
Our Laundry Detergent Sheets provide 260 loads of cleaning power. They are eco-friendly and cost just $0.04 per load.
These sheets clean clothes effectively with their ultra-concentrated formula. They contain natural botanicals that are gentle on skin. The sheets work on all types of textiles.
Say goodbye to messy spills and plastic waste. Each pre-cut sheet is simple to use. They work in all washing machines.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This laundry detergent sheet is perfect for families, students, and renters who want clean clothes, save money, and avoid harsh chemicals. It is also great for anyone with sensitive skin or who cares about the eco‑friendly, no‑plastic design.
Ready to Purchase?
10. Amazing Natural Based Laundry Detergent – Powerful Natural Enzymes – USA Made (128oz Bottle)
Our natural laundry detergent removes tough stains from all fabrics. It uses powerful enzymes to clean without harsh chemicals.
The detergent is cost-effective and lasts for many loads. It is made in the USA by a family company. Your clothes will smell fresh and clean.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This natural laundry detergent is perfect for busy families with active kids and stained clothes. It works great for athletes who need to clean smelly gear without harsh chemicals.
Ready to Purchase?
Buying Guide
Enzyme detergents clean clothes deeply. They remove tough stains and odors. These detergents work well in all water types.
I tried enzyme detergent on my gym clothes. The sweat smell vanished. My clothes felt fresh and lasted longer.
- Enzyme Types: Different enzymes target different stains. Protease breaks down proteins. Amylase tackles starches.
- Form: Powders are often concentrated. Sheets are easy to use and store. Liquids dissolve quickly.
- Scent: Unscented options are best for sensitive skin. Some detergents have natural scents. Avoid strong artificial fragrances.
- Eco-Friendliness: Look for plastic-free packaging. Biodegradable formulas help the planet. Some brands are carbon negative.
- Skin Sensitivity: Hypoallergenic detergents are gentle. They lack harsh chemicals. Safe for babies and sensitive skin.
- Concentration: Concentrated formulas last longer. They save money and space. Use less per load.
- Water Temperature: Most enzymes work in cold water. This saves energy. Check if the detergent works in hot water too.
- Stain Fighting Power: Enzymes break down stains at the molecular level. They remove oil, sweat, and grass. Look for multiple enzymes.
- Cost Per Load: Calculate the price per load. Sheets and powders often offer more loads. This saves money over time.
- Brand Reputation: Choose trusted brands. Read reviews from other users. Good brands stand by their products.