What are the best enzyme-based detergents? Discover 10 top recommendations based on real users’ experiences with fresh, clean results on workout clothes and pet messes.
Enzyme-based detergents offer a smart way to clean clothes. They use natural enzymes to break down tough stains. Many users find them gentle yet powerful.
People love how these products freshen workout clothes. A runner shared that her gym shirt stayed odor-free after washing.
These detergents work well on pet messes too. Choose the right one for your needs. You’ll get fresh, clean results every time.
List of Top 10 Enzyme Based Detergents
| Image | Title | Best For | Price |
|---|---|---|---|
 |
Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads |
Perfect for anyone who wants clean, unscented clothes. It uses bio enzymes to fight stains like sweat, grease, oil, and blood and works with all washers and detergents. |
|
 |
Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads |
This product is perfect for busy pet owners who deal with dog beds, cat pee stains, and wet dog smells every day. It helps clean pet blankets, leashes, and even your own clothes that pick up pet odors, making laundry easy and fresh. |
|
 |
Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads) |
This product is perfect for families who want safe, natural laundry care in a busy home. It’s great for parents with kids or pets who seek gentle, effective cleaning without harsh chemicals. |
|
 |
Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Machine Washing | Nontoxic, Biodegradable | Stain & Odor Removal |
This detergent is perfect for families with babies and pets. It is ideal for anyone with sensitive skin who wants a scent-free, non-toxic clean. |
|
 |
2 PCS Active Enzyme Laundry Detergent, Active Enzyme Laundry Stain Remover, Garment Stubborn Stain Cleaner Oil Remover, Clothes Oil Stain RemoverWhite Shirt Guardian |
This product is perfect for busy families and anyone who deals with stains daily. With plant-based enzymes, it removes stains fast on shirts, pants, and other fabrics, whether you’re at home or on the go. |
|
 |
Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 16 fl oz, 64 Loads) |
Dealing with sensitive skin or allergies? Want clean laundry without harsh chemicals? This plant-based detergent is perfect for you! |
|
 |
Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads) |
This Active Wear Laundry Detergent is perfect for anyone who loves to work out. It’s great for removing smells from your activewear! |
|
 |
Enzyme Laundry Booster Additive, Unscented. 48 Load Laundry Sanitizer Detergent, Color Safe Fabric Active Enzyme Washing Soda Detergent Cleaner. Powdered Stain Treater & Odor Remover Booster Treatment |
Defunkify is perfect for busy parents with kids and pets who need safe, gentle cleaning for everyday messes. It works great for athletes and outdoor lovers who want to remove tough sweat smells from activewear without harsh chemicals. |
|
 |
Laundry Detergent Sheets (120 Loads) Eco-Friendly, Hypoallergenic, & Enzyme-Based Powerful Stain Removal – Convenient for Travel & Space-Saving – Fresh Scent (Fresh Scent) |
This product is perfect for anyone who wants easy, eco-friendly laundry and a gentle touch on clothes. It’s ideal for TRAVEL-FRIENDLY use, people in SPACE-SAVING homes, and busy households because these PRE-MEASURED and SPILL-FREE sheets fit any washer, any water temperature, and leave fabrics clean and fresh. |
|
 |
Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor |
It is perfect for busy households needing a simple, fragrance-free clean that fights stains and odors. It works for those with sensitive skin, families, and anyone who wants a plastic-free, carbon-negative option with 48 pre-measured strips. |
Detailed Reviews
Expert analysis and customer feedback have shaped this top 10 list of enzyme-based detergents for the best stain and odor removal. Each product stands out with powerful enzymes that clean gently and safely on all fabrics, backed by detailed reviews of their features and value. You’ll discover the perfect match for your laundry needs that keeps clothes fresh and spotless—dive in to find out which ones shine brightest.
1. Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads
Say goodbye to stubborn stains and unpleasant odors! This Enzyme Laundry Booster is your new secret weapon. It’s packed with powerful enzymes. Get ready for fresh, clean clothes.
Our laundry additive is a stain-fighting machine. It tackles sweat, oil, blood, and more. It’s also gentle on all your fabrics. Use it on whites, colors, and even activewear.
This 2-pound package gives you 64 loads of cleaning power. It works with all washers and detergents.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Perfect for anyone who wants clean, unscented clothes. It uses bio enzymes to fight stains like sweat, grease, oil, and blood and works with all washers and detergents.
Ready to Purchase?
2. Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads
ACTIVE Pet Laundry Detergent tackles tough pet messes with enzyme power. It removes odors and stains from your pet items fast.
This powder works on pet beds, blankets, and more. It cleans urine, drool, and dirt well. Use it in any washer, even cold water.
ACTIVE is natural and safe for pets and skin. It beats smells without fake scents. Get 64 loads in one value pack for easy care.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This product is perfect for busy pet owners who deal with dog beds, cat pee stains, and wet dog smells every day. It helps clean pet blankets, leashes, and even your own clothes that pick up pet odors, making laundry easy and fresh.
Ready to Purchase?
3. Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)
Puracy Laundry Detergent is a natural and non-toxic liquid concentrate. It comes in a 16 oz bottle that gives you 64 loads of clean washing.
It fights tough stains like chocolate, grease, and mud. The plant-based enzymes keep fabrics soft and new. It’s kind to all clothes, from baby outfits to jeans.
A team of chemists made this product safe. It uses only plant and mineral ingredients. It’s good for homes with kids and pets.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This product is perfect for families who want safe, natural laundry care in a busy home. It’s great for parents with kids or pets who seek gentle, effective cleaning without harsh chemicals.
Ready to Purchase?
4. Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Machine Washing | Nontoxic, Biodegradable | Stain & Odor Removal
Dirty Labs is a scent-free liquid laundry soap made with bio enzyme technology. It cleans clothes well without harsh chemicals, so it is safe for all people and pets.
This detergent works hard on stains and smells, using powerful yet gentle plant-based ingredients. It uses less water than regular soaps and comes in a small bottle that you can recycle.
Use just a little bit – about 1/2 teaspoon for medium loads – and follow your washer’s rules. It works in cold water and is free from dyes and sulfates.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This detergent is perfect for families with babies and pets. It is ideal for anyone with sensitive skin who wants a scent-free, non-toxic clean.
Ready to Purchase?
5. 2 PCS Active Enzyme Laundry Detergent, Active Enzyme Laundry Stain Remover, Garment Stubborn Stain Cleaner Oil Remover, Clothes Oil Stain RemoverWhite Shirt Guardian
Fast stain remover. Works in seconds. Stains disappear.
Plant-based enzymes power its cleaning. Safe for white, dark, and colored fabrics.
Compact design makes it easy to carry. Great for spills at home or on the go. Always ready to tackle tough stains.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This product is perfect for busy families and anyone who deals with stains daily. With plant-based enzymes, it removes stains fast on shirts, pants, and other fabrics, whether you’re at home or on the go.
Ready to Purchase?
6. Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 16 fl oz, 64 Loads)
Get ready for clean and fresh laundry! Puracy Laundry Detergent uses plant-powered ingredients. It is safe for your family and the planet.
This detergent is gentle on clothes. It is also safe for sensitive skin.
Puracy is made in the USA. It is never tested on animals.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Dealing with sensitive skin or allergies? Want clean laundry without harsh chemicals? This plant-based detergent is perfect for you!
Ready to Purchase?
7. Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads)
This detergent fights off nasty sweat smells in gym clothes. It uses natural plant-based enzymes for a fresh clean.
Made in the USA with safe plant-based ingredients. Free from SLS, phosphates, and gluten. Septic safe and kind to your tank.
Works on shirts, shorts, leggings, and socks. Concentrated formula gives 90 loads. Protects and extends your activewear’s life.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This Active Wear Laundry Detergent is perfect for anyone who loves to work out. It’s great for removing smells from your activewear!
Ready to Purchase?
8. Enzyme Laundry Booster Additive, Unscented. 48 Load Laundry Sanitizer Detergent, Color Safe Fabric Active Enzyme Washing Soda Detergent Cleaner. Powdered Stain Treater & Odor Remover Booster Treatment
Defunkify is an enzyme laundry booster that supercharges your regular detergent. It uses natural ingredients to remove stains and smells in just one wash. This unscented powder keeps fabrics fresh and clean.
It’s safe for sensitive skin, kids, and pets. The ProvenSafe formula is eco-friendly with no harsh chemicals. Try Defunkify today for the safest laundry boost.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Defunkify is perfect for busy parents with kids and pets who need safe, gentle cleaning for everyday messes. It works great for athletes and outdoor lovers who want to remove tough sweat smells from activewear without harsh chemicals.
Ready to Purchase?
9. Laundry Detergent Sheets (120 Loads) Eco-Friendly, Hypoallergenic, & Enzyme-Based Powerful Stain Removal – Convenient for Travel & Space-Saving – Fresh Scent (Fresh Scent)
Tired of messy laundry? These detergent sheets are the answer! They make washing clothes easy and clean. Get ready for fresh, stain-free clothes.
These eco-friendly sheets are safe for everyone. They clean, soften, and remove wrinkles. Even better, they work in all washing machines.
Take them when you travel. Laundry is now simple and quick!
| Pros | Cons |
|---|---|
|
|
Perfect For:
This product is perfect for anyone who wants easy, eco-friendly laundry and a gentle touch on clothes. It’s ideal for TRAVEL-FRIENDLY use, people in SPACE-SAVING homes, and busy households because these PRE-MEASURED and SPILL-FREE sheets fit any washer, any water temperature, and leave fabrics clean and fresh.
Ready to Purchase?
10. Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor
Clean laundry starts here. Five-enzyme power fights stains. Unscented and gentle on skin.
Each box has 48 pre-measured strips. Plastic-free packaging uses recyclable cardboard.
Carbon-negative and certified by the Clean Earth Collective. We offset the rest twice with credits to fund projects.
| Pros | Cons |
|---|---|
|
|
Perfect For:
It is perfect for busy households needing a simple, fragrance-free clean that fights stains and odors. It works for those with sensitive skin, families, and anyone who wants a plastic-free, carbon-negative option with 48 pre-measured strips.
Ready to Purchase?
Buying Guide
Enzyme-based detergents use natural enzymes to fight tough stains. They keep clothes fresh and clean without harsh chemicals. Many people choose them for everyday laundry needs.
Users share how these detergents work wonders. A runner says her gym shirt stays odor-free after washing. A pet owner cleans urine stains on dog beds easily. Families appreciate the gentle power for baby clothes too.
Factors to Consider:
- Effectiveness on Stains: Check if the product handles sweat, oil, and blood well. Look for enzyme boosters that freshen workout or pet items. Test on your common stains for best results.
- Scent Options: Pick a scent-free version for sensitive noses. Some offer fresh linen or unscented choices. Avoid strong smells if you want natural clean.
- Safety and Gentle Formula: Ensure it’s safe for skin, pets, and babies. Look for plant-based ingredients without harsh chemicals. Choose products that are non-toxic and biodegradable. Test for skin reactions to be sure.
- Machine Compatibility: Make sure it works in your washer type, like high-efficiency models. Some are great for cold water washing. Check if it pairs with your regular detergent well.
- Type of Product: Decide between powder, liquid, strips, or sheets. Powders last long for many loads. Liquids are easy to pour. Strips are convenient for travel or small spaces.
- Load Count and Concentration: See how many loads one package gives. Concentrated forms like a small bottle for 64 loads save space. Calculate cost per wash to find value.
- Eco-Friendly Aspects: Opt for biodegradable and septic-safe options. Look for carbon-negative or recyclable packaging. Support brands that use plant-based enzymes for the environment.
- Price and Availability: Compare costs per load across brands. Shop for sales or bundles. Buy from trusted stores for quality assurance.