10 Best Enzyme-Powered Laundry Detergents: Safe & Effective Picks

Are you curious about the top enzyme-powered laundry detergents? I’m here to help you discover the best options that combine power, safety, and convenience for your laundry needs.

Enzyme-powered laundry detergents are a game-changer for tackling tough stains and odors. They use natural enzymes to break down dirt, leaving clothes fresh and clean. These detergents are perfect for activewear, pet stains, and everyday messes.

Choosing the right one can make laundry day easier and more effective. From powders to liquids and even sheets, there’s a product for every need. They’re also gentle on fabrics and safe for sensitive skin, making them a great choice for families.

Ready to find the best enzyme detergent for you? Let’s explore the top options that combine power, safety, and convenience. Your clothes will thank you!

List of Top 10 Enzyme-Powered Laundry Detergents

Image Title Best For Price
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads

This enzyme laundry booster is perfect for anyone who wants to remove tough stains and odors from their clothes. It’s great for activewear, whites, and colors, and works with all washers and detergents.

Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High Efficiency & Standard Machine Washer | Nontoxic, Biodegradable | Stain & Odor Removal Enzyme Booster Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High Efficiency & Standard Machine Washer | Nontoxic, Biodegradable | Stain & Odor Removal Enzyme Booster

Parents with sensitive-skinned babies, eco-conscious shoppers, and anyone battling stubborn sweat or blood stains need this. It’s 100% safe for little ones and pets, hypoallergenic, and free of toxins, dyes, and synthetic fragrances. Just add it to your wash—works in cold water, protects your machine, and leaves fabrics genuinely clean without harsh chemicals.

Pro-Enzyme Laundry Detergent Powder, Non-Irritating Professional Strength Natural Active Enzymes - Powerful Sweat, Odor & Stain Remover for Activewear, Clothing, Bedding, Use in All Machines, 96 Loads Pro-Enzyme Laundry Detergent Powder, Non-Irritating Professional Strength Natural Active Enzymes – Powerful Sweat, Odor & Stain Remover for Activewear, Clothing, Bedding, Use in All Machines, 96 Loads

Perfect for those with active lifestyles or sensitive skin, this detergent tackles tough sweat, odors, and stains on activewear, clothes, and bedding. Ideal for eco-conscious users, it’s gentle yet powerful, works in all machines, and lasts for 96 loads.

Rockin’ Green Active Wear Laundry Detergent - Unscented Laundry Detergent Powder & Odor Eliminator - Workout Clothes & Sportswear - Safe for Sensitive Skin - 90 Loads Rockin’ Green Active Wear Laundry Detergent – Unscented Laundry Detergent Powder & Odor Eliminator – Workout Clothes & Sportswear – Safe for Sensitive Skin – 90 Loads

This detergent is perfect for active individuals and those with sensitive skin who want to clean activewear, gym clothes, and leggings without harsh chemicals. It eliminates tough odors and preserves fabric performance while staying safe for sensitive skin.

Puracy Laundry Detergent - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads) Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

This plant-powered, non-toxic detergent is perfect for families with kids, pets, or sensitive skin. It tackles tough stains and protects fabrics while staying free & clear of harsh chemicals.

Nature’s Miracle Laundry Boost In-Wash Stain and Odor Remover, 32 Ounces, Laundry Stain and Odor Removing Additive For All Machines Nature’s Miracle Laundry Boost In-Wash Stain and Odor Remover, 32 Ounces, Laundry Stain and Odor Removing Additive For All Machines

This product is perfect for pet owners tackling tough stains and odors. It breaks down urine, feces, and blood safely, works in all machines, and is gentle on fabrics.

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads

This pet laundry detergent is perfect for pet owners who want to remove tough stains and odors from their pet’s items. It’s great for cleaning beds, clothes, and more, leaving everything fresh and clean.

Persil Advanced Clean Oxi+Odor Power, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, Ultra Concentrated, 82.5 fl oz, 82 Loads Persil Advanced Clean Oxi+Odor Power, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, Ultra Concentrated, 82.5 fl oz, 82 Loads

Persil Advanced Clean Oxi+Odor Power is perfect for busy households tackling tough stains and odors. It’s ideal for those with HE machines who want deep stain removal, odor elimination, and fabric protection in one ultra-concentrated formula.

Sunny Goods Laundry Detergent Sheets with Plant Powered Stain-Fighting Enzymes - 60 Loads - Concentrated Liquidless Laundry Soap Sheets - Home and Travel Laundry Detergent - Unscented Sunny Goods Laundry Detergent Sheets with Plant Powered Stain-Fighting Enzymes – 60 Loads – Concentrated Liquidless Laundry Soap Sheets – Home and Travel Laundry Detergent – Unscented

These laundry detergent sheets are perfect for anyone who wants an easy way to do laundry. They are great for people who travel or have small spaces.

Puracy Laundry Detergent Refill - Enzyme-Powered Liquid Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 48 fl oz, 192 Loads) Puracy Laundry Detergent Refill – Enzyme-Powered Liquid Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 48 fl oz, 192 Loads)

This Puracy Laundry Detergent is perfect for families. It’s also great for people who want safe and effective cleaning.

Detailed Reviews

Discover the top 10 enzyme-powered laundry detergents that combine expert analysis and customer feedback for the best results. Each product is thoroughly reviewed to highlight its features, performance, and value. Whether you need comfort, affordability, or powerful cleaning, this guide has you covered. Find the perfect enzyme detergent to keep your clothes fresh, clean, and stain-free every time.

1. Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

The Enzyme Laundry Booster Odor Remover is a powerful stain cleaner designed for your laundry. It works alongside your regular detergent to effectively target and remove tough odors and stains.

This product is tough on stains like sweat, blood, and oil. It is gentle on all fabrics and safe for colors. Use it to boost your cleaning power!

With this 2 lbs package, you can treat up to 64 loads of laundry. It is compatible with all washers, making it easy to use. Enjoy fresh, clean clothes without harsh chemicals!

Pros Cons
  • Powerful stain and odor removal for laundry.
  • Gentle on all fabrics, safe for activewear.
  • Value pack cleans up to 64 loads.
  • Compatible with all washers and detergents.
  • May not work on all tough stains.
  • Unscented formula might not appeal to everyone.
  • Requires additional steps for best results.

Perfect For:

This enzyme laundry booster is perfect for anyone who wants to remove tough stains and odors from their clothes. It’s great for activewear, whites, and colors, and works with all washers and detergents.

Ready to Purchase?

2. Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High Efficiency & Standard Machine Washer | Nontoxic, Biodegradable | Stain & Odor Removal Enzyme Booster

Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High Efficiency & Standard Machine Washer | Nontoxic, Biodegradable | Stain & Odor Removal Enzyme Booster

Dirty Labs offers a powerful Scent Free Bio Enzyme Laundry Booster. This product is safe for both you and the environment.

The formula is made from 100% bio and mineral-based ingredients. It effectively removes tough stains and odors. This makes laundry day easier and cleaner.

Each package provides 48 loads of laundry. It’s suitable for both standard and high-efficiency washers. Plus, it is hypoallergenic and safe for babies and pets.

Pros Cons
  • Nontoxic and biodegradable for a safer wash.
  • Fights tough stains and odors effectively.
  • Environmentally friendly with recyclable packaging.
  • Works in both standard and HE washers.
  • Safe for sensitive skin, babies, and pets.
  • May not remove all tough stains effectively.
  • Higher price compared to regular laundry boosters.
  • Limited scent options for those who prefer fragrances.

Perfect For:

Parents with sensitive-skinned babies, eco-conscious shoppers, and anyone battling stubborn sweat or blood stains need this. It’s 100% safe for little ones and pets, hypoallergenic, and free of toxins, dyes, and synthetic fragrances. Just add it to your wash—works in cold water, protects your machine, and leaves fabrics genuinely clean without harsh chemicals.

Ready to Purchase?

3. Pro-Enzyme Laundry Detergent Powder, Non-Irritating Professional Strength Natural Active Enzymes – Powerful Sweat, Odor & Stain Remover for Activewear, Clothing, Bedding, Use in All Machines, 96 Loads

Pro-Enzyme Laundry Detergent Powder, Non-Irritating Professional Strength Natural Active Enzymes - Powerful Sweat, Odor & Stain Remover for Activewear, Clothing, Bedding, Use in All Machines, 96 Loads

Introducing the Pro-Enzyme Laundry Detergent Powder, a natural and powerful cleaner for your clothes. It is specially designed to fight stubborn sweat, odors, and stains. Perfect for activewear and everyday clothing, it works in all types of washing machines.

It’s gentle on fabrics but tough on dirt. All you need is a small amount for over 90 loads. It revives colors, brightens whites, and removes odors naturally using plant-based ingredients.

Made with premium enzymes and citrus oils, this detergent is eco-friendly and septic-safe. It ensures your clothes smell fresh, clean, and feel soft every time. Plus, your satisfaction is guaranteed with our 100% money-back promise.

Pros Cons
  • Eliminates tough odors from activewear effectively
  • Gentle on fabrics but powerful in cleaning
  • Eco-friendly with natural ingredients, free from harsh chemicals
  • Compatible with all washing machines, including high efficiency
  • Long-lasting: cleans over 90 loads in one bag
  • Powder may not dissolve fully in some machines
  • Light natural scent may not last long on clothes
  • Messy powder handling compared to liquid detergents

Perfect For:

Perfect for those with active lifestyles or sensitive skin, this detergent tackles tough sweat, odors, and stains on activewear, clothes, and bedding. Ideal for eco-conscious users, it’s gentle yet powerful, works in all machines, and lasts for 96 loads.

Ready to Purchase?

4. Rockin’ Green Active Wear Laundry Detergent – Unscented Laundry Detergent Powder & Odor Eliminator – Workout Clothes & Sportswear – Safe for Sensitive Skin – 90 Loads

Rockin’ Green Active Wear Laundry Detergent - Unscented Laundry Detergent Powder & Odor Eliminator - Workout Clothes & Sportswear - Safe for Sensitive Skin - 90 Loads

Rockin’ Green Active Wear Laundry Detergent is perfect for your workout clothes. It breaks down sweat and odors with plant-based enzymes. Your gym gear will stay fresh and clean after every wash.

This detergent protects high-tech fabrics and microfibers. It helps keep your workout clothes stretchy and breathable. The formula is gentle and free from harsh chemicals.

Just one bag lasts for up to 90 loads. You only need one scoop for a deep clean. It works in all washing machines, including high-efficiency models. You can also use it as a pre-soak for tough odors.

Pros Cons
  • Removes sweat and odors for all-day freshness
  • Protects high-tech fibers and fabrics
  • Gentle and safe for sensitive skin
  • Covers up to 90 loads with one bag
  • Made with natural ingredients and cruelty-free
  • No scent may disappoint those who prefer fragrant laundry.
  • Powder form requires measuring, less convenient than liquids.
  • May require pre-treatment for stubborn stains despite odor claims.

Perfect For:

This detergent is perfect for active individuals and those with sensitive skin who want to clean activewear, gym clothes, and leggings without harsh chemicals. It eliminates tough odors and preserves fabric performance while staying safe for sensitive skin.

Ready to Purchase?

5. Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

Puracy Laundry Detergent - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

Puracy Laundry Detergent is enzyme-powered and plant-based, made to tackle stains safely. This non-toxic formula works in a 16 fl oz bottle for up to 64 loads, cutting waste while cleaning deeply.

It fights common messes like chocolate, grease, or mud without harsh chemicals. Gentle on delicate fabrics and sturdy clothes, it keeps all garments fresh and lasting longer.

Safe for kids and pets. Expertly crafted by chemists using mineral and plant-based ingredients. A trusted choice for clean clothes and a calmer home.

Pros Cons
  • Concentrated formula does 64 loads, saving money and reducing plastic waste.
  • Plant-powered enzymes tackle stains safely, ideal for sensitive skin.
  • Free & clear scent leaves clothes fresh without harsh chemicals.
  • Gentle on fabrics from baby clothes to tough denim.
  • Non-toxic ingredients ensure safety for kids and pets.
  • Higher price tag than average detergents.
  • Subtle scent may not satisfy fragrance lovers.
  • Concentrated formula might need careful measuring for best results.

Perfect For:

This plant-powered, non-toxic detergent is perfect for families with kids, pets, or sensitive skin. It tackles tough stains and protects fabrics while staying free & clear of harsh chemicals.

Ready to Purchase?

6. Nature’s Miracle Laundry Boost In-Wash Stain and Odor Remover, 32 Ounces, Laundry Stain and Odor Removing Additive For All Machines

Nature’s Miracle Laundry Boost In-Wash Stain and Odor Remover, 32 Ounces, Laundry Stain and Odor Removing Additive For All Machines

Say goodbye to tough pet stains and odors with Nature’s Miracle Laundry Boost! This In-Wash Stain and Odor Remover is designed to tackle the toughest messes, from urine and feces to vomit and grass. It’s the perfect solution for pet owners who want clean, fresh-smelling clothes and linens.

Powerful bio-enzymatic formula breaks down and destroys tough stains and odors, leaving your laundry smelling fresh and clean. Plus, it’s safe for use on most fabrics and in all washing machines, including HE machines.

Pros Cons
  • Tough on stains, gentle on fabrics, perfect for pet owners!
  • Removes urine, feces, vomit, and other nasty odors.
  • Safe for pets and home, no harsh chemicals used.
  • Works in all machines, including HE, no hassle.
  • OdorCapt 360 technology neutralizes smells, not just masks them.
  • Not safe for delicate fabrics like silk, wool, or leather
  • Less effective on non-pet stains like oil or ink

Perfect For:

This product is perfect for pet owners tackling tough stains and odors. It breaks down urine, feces, and blood safely, works in all machines, and is gentle on fabrics.

Ready to Purchase?

7. Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads

Tired of pet odors and stains? ACTIVE Pet Laundry Detergent is here! It’s a powerful enzyme-based powder detergent. This detergent is designed to make your life easier.

This detergent is great for all your pet laundry needs. It works on beds, clothing, and more. It removes odors instead of just covering them up.

Get a 64-load value pack. It’s natural, fragrance-free, and safe for your pets. Your home will smell fresh and clean.

Pros Cons
  • Removes tough stains and odors effectively.
  • Safe for pets and sensitive skin.
  • Concentrated formula for 64 loads of cleaning.
  • Works on all fabric types and pet items.
  • Natural and fragrance-free for a clean scent.
  • Not ideal for quick spot-cleaning; requires full wash cycle.
  • Powder can clump if stored in humid areas.
  • May need pre-soak for older, set-in stains.

Perfect For:

This pet laundry detergent is perfect for pet owners who want to remove tough stains and odors from their pet’s items. It’s great for cleaning beds, clothes, and more, leaving everything fresh and clean.

Ready to Purchase?

8. Persil Advanced Clean Oxi+Odor Power, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, Ultra Concentrated, 82.5 fl oz, 82 Loads

Persil Advanced Clean Oxi+Odor Power, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, Ultra Concentrated, 82.5 fl oz, 82 Loads

Persil Advanced Clean Oxi+Odor Power is a powerful liquid laundry detergent. It delivers a premium deep clean with every wash. This ultra-concentrated formula is designed for high-efficiency machines.

The detergent fights tough stains and eliminates odors. It also protects fabrics, keeping whites and colors vibrant. Your clothes will look newer for longer.

With 82.5 fl oz, you get 82 loads of clean, fresh laundry. This 2X concentrated formula means less product, more power. Trust Persil for a superior clean every time.

Pros Cons
  • Deep cleans and removes tough stains with every wash.
  • Protects fabrics, keeping whites and colors vibrant.
  • Ultra-concentrated formula means less detergent, more power.
  • Eliminates odors while preserving clothes’ freshness.
  • Ultra-concentrated formula requires careful measuring.
  • Not compatible with non-HE washing machines.

Perfect For:

Persil Advanced Clean Oxi+Odor Power is perfect for busy households tackling tough stains and odors. It’s ideal for those with HE machines who want deep stain removal, odor elimination, and fabric protection in one ultra-concentrated formula.

Ready to Purchase?

9. Sunny Goods Laundry Detergent Sheets with Plant Powered Stain-Fighting Enzymes – 60 Loads – Concentrated Liquidless Laundry Soap Sheets – Home and Travel Laundry Detergent – Unscented

Sunny Goods Laundry Detergent Sheets with Plant Powered Stain-Fighting Enzymes - 60 Loads - Concentrated Liquidless Laundry Soap Sheets - Home and Travel Laundry Detergent - Unscented

Sunny Goods Laundry Detergent Sheets make laundry easy. No harsh chemicals, just powerful enzymes that fight stains.

Lightweight, travel-friendly, and mess-free. Works in any machine, any cycle, any water temperature.

Pros Cons
  • No harsh chemicals, just enzyme-powered stain removal for a powerful clean.
  • Plastic-free, lightweight, and travel-friendly—perfect for on-the-go laundry.
  • No mess, no measuring—just toss and wash with ease.
  • Fast-dissolving sheets work in any cycle, hot or cold.
  • Unscented sheets may not appeal to those who prefer fresh smells.
  • No fabric softener included, requiring an extra product for softness.
  • Higher cost per load compared to bulk liquid detergents.

Perfect For:

These laundry detergent sheets are perfect for anyone who wants an easy way to do laundry. They are great for people who travel or have small spaces.

Ready to Purchase?

10. Puracy Laundry Detergent Refill – Enzyme-Powered Liquid Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 48 fl oz, 192 Loads)

Puracy Laundry Detergent Refill - Enzyme-Powered Liquid Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 48 fl oz, 192 Loads)

One pump cleans a full load. Puracy Laundry Detergent Refill packs serious stain-fighting power into a tiny, concentrated bottle. 48 fl oz gives you 192 loads—less plastic, more savings, zero waste.

Plant enzymes lift dirt and odors without harsh chemicals, keeping clothes fresh, soft, and safe for sensitive skin. Tough on stains, gentle on fabrics, from baby onesies to your favorite jeans. Trust PhD-crafted ingredients that protect what matters—your family, your pets, your peace of mind.

Pros Cons
  • Non-toxic formula is safe for sensitive skin.
  • Plant-based ingredients help protect the environment.
  • Effectively removes stains from various fabrics.
  • Lasts longer with up to 192 loads per refill.
  • Gentle on both delicate and sturdy clothing.
  • Requires dilution for use, adding extra steps.
  • Mild scent may not satisfy those wanting strong freshness.
  • Liquid refill packaging could risk spills if not sealed properly.

Perfect For:

This Puracy Laundry Detergent is perfect for families. It’s also great for people who want safe and effective cleaning.

Ready to Purchase?

Buying Guide

Enzyme-powered detergents make laundry easy. They tackle tough stains without harsh chemicals.

  • Type of Detergent: Choose between powders, liquids, or sheets. Each works well, but pick what fits your routine.
  • Stain-Fighting Power: Targets sweat, blood, oil, and pet messes. Enzymes break down proteins and fats for a deep clean.
  • Fabric Safety: Gentle on clothes and colors. Keeps activewear stretchy and soft without damage.
  • Machine Compatibility: Works in standard and high-efficiency (HE) washers. Check labels to match your machine.
  • Eco-Friendly Ingredients: Made with plant-based, biodegradable formulas. Safe for kids, pets, and the planet.
  • Scent Options: Pick unscented or fragrance-free for sensitive skin. No fake perfumes, just fresh, clean results.
  • Load Count: Packs last from 48 to 192 loads. Bigger sizes save money and trips to the store.
  • Odor Elimination: Destroys smells from sweat, urine, or food. No masking—just pure, lasting freshness.
  • Extra Features: Some double as pre-soaks or boosters. Look for hypoallergenic, septic-safe, or travel-friendly picks.

Your laundry routine just got smarter. Fresh, clean clothes are one choice away!