10 Best Natural Enzymatic Detergents: Clean & Fresh

What are the best natural enzymatic detergents?
Discover our expert recommendations and simple tips to enjoy fresher, cleaner clothes without harsh chemicals in every load.

Natural enzymatic detergents clean clothes well with plant-based power. A user said their laundry smelled fresh for days after using one, saving time and money. You can trust our expert guide for the best choices that fit your needs.

We picked top products based on real reviews and safe formulas. These detergents fight stains without harsh chemicals. Get ready to learn simple tips to boost your washing routine.

Pick one today for cleaner clothes. Feel the difference in every load. Start your journey to better laundry now.

List of Top 10 Natural Enzymatic Detergents

Image Title Best For Price
Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1 Liter, 67 Loads Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1 Liter, 67 Loads

This laundry detergent is perfect for anyone who wants a powerful and eco-friendly way to clean their clothes. It’s great for people who care about the environment and want a safe product.

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads

This detergent is perfect for dog owners and cat owners who want to easily clean pet beds, clothes, and furniture from stubborn smells like urine or drool. It’s also ideal for anyone with sensitive skin or those who prefer natural ways to remove odors without harsh scents.

Puracy Laundry Detergent - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads) Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

Puracy Laundry Detergent is perfect for families who want gentle, natural care for clothes, kids, and pets. It’s ideal for anyone with skin sensitivities seeking fresh, spot-free laundry without harsh chemicals.

Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, Free & Clear Unscented, 1.5 Liter, 100 Loads Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, Free & Clear Unscented, 1.5 Liter, 100 Loads

This laundry detergent is perfect for families who want safe, eco-friendly laundry options. It also suits people with sensitive skin who seek a cruelty-free, scent-free choice.

Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1.5 Liter, 100 Loads Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1.5 Liter, 100 Loads

This ultra concentrated laundry detergent is perfect for families who need strong, plant-based cleaning without harmful chemicals and wasted space. It’s also ideal for people who care about the environment and want safe, eco-friendly care for their clothes.

Puracy Laundry Detergent Refill - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 48 fl oz, 192 Loads) Puracy Laundry Detergent Refill – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 48 fl oz, 192 Loads)

This natural laundry detergent is perfect for people with sensitive skin or allergies. It gives you clean clothes without any harsh chemicals that could bother your skin.

Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips - Unscented, 48 Loads - Sulfate Free Laundry Detergent With Solid And Liquid Enzymes - Fights Natural Stains and Odor Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor

This laundry detergent is perfect for busy families and eco-conscious people who want a simple, clean solution without harmful chemicals. It’s also ideal for those with sensitive skin seeking a fragrance-free option that fights stains and odors easily.

Biokleen Laundry Detergent Sheets - Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads Biokleen Laundry Detergent Sheets – Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads

Biokleen Laundry Detergent Sheets are perfect for people who want clean clothes without harmful chemicals, such as those with sensitive skin or allergies.
They also suit eco-friendly families and travelers looking for easy, mess-free laundry that saves money and helps the planet.

Active Wear Laundry Detergent & Soak - Formulated for Sweat and Workout Clothes - Natural Performance Concentrate Enzyme Booster Deodorizer - Powder Wash for Activewear Gym Apparel (90 Loads) Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads)

This Active Wear Laundry Detergent is perfect for active people who wear gym clothes often. It removes sweat smells from shirts, shorts, leggings, and socks in a natural way.

LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner - 64 Oz (96 Washes) Pet Stain and Odor Eliminator, Enzymatic Detergent by Alpha Tech Pet LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner – 64 Oz (96 Washes) Pet Stain and Odor Eliminator, Enzymatic Detergent by Alpha Tech Pet

LaundraPet is perfect for pet owners who need to remove tough stains and odors from poop, urine, or dirt on clothes. It works great for groomers, vets, and kennel workers who want a safe, effective cleaner that saves money on 96 washes.

Detailed Reviews

Natural enzymatic detergents offer gentle, effective cleaning with plant-based formulas. Our guide highlights the top 10 picks after careful expert analysis and real customer feedback. Discover detergents that fight stains, remove odors, and care for your clothes without harsh chemicals. Dive in to find the perfect match for your laundry needs.

1. Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1 Liter, 67 Loads

Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1 Liter, 67 Loads

Root & Splendor is an ultra concentrated laundry detergent. It comes in a plant-based formula with enzymes. Just use 1 tablespoon for a regular load.

This detergent works in all machines, even HE ones. It uses bag-in-box packaging to cut down on waste.

The 2250 scent has patchouli and lemongrass oils. It is cruelty-free and safe for your family. A mom makes it in the USA with care.

Pros Cons
  • Ultra concentrated formula uses just 1 tablespoon per load.
  • Eco-friendly packaging cuts pollution by 800%.
  • Non-toxic and cruelty-free for all machines.
  • Natural scents from essential oils like lemongrass.
  • USA-made by a woman-owned business.
  • Too potent for light washes, may sting fabric.
  • Bag-in-box design can be messy to handle.
  • May leave residue on tough soils if under-dosed.

Perfect For:

This laundry detergent is perfect for anyone who wants a powerful and eco-friendly way to clean their clothes. It’s great for people who care about the environment and want a safe product.

Ready to Purchase?

2. Pet Laundry Detergent Odor Remover – ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator – 64 Loads

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads

ACTIVE Pet Laundry Detergent is a strong, concentrated powder that kills odors and removes stains from pet messes. It works on dog beds, cat pee, dog drool, and even your own clothes and bedding. This enzyme-based cleaner is natural, fragrance-free, and safe for pets and sensitive skin.
Use one to two scoops per load in your HE washer, and it handles 64 loads. For tough stains, soak items in water with the detergent first.

Pros Cons
  • Powerful enzymes eliminate tough pet odors and stains.
  • Safe for all fabrics, from dog beds to your clothes.
  • Gentle formula with no harsh chemicals.
  • Great value: 64 loads in just one bag.
  • Easy to use with simple instructions.
  • Might need pre-soaking for tough stains.
  • Powder can be messy to handle.
  • Big bag takes more space to store.

Perfect For:

This detergent is perfect for dog owners and cat owners who want to easily clean pet beds, clothes, and furniture from stubborn smells like urine or drool. It’s also ideal for anyone with sensitive skin or those who prefer natural ways to remove odors without harsh scents.

Ready to Purchase?

3. Puracy Laundry Detergent – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

Puracy Laundry Detergent - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Free & Clear, 16 fl oz, 64 Loads)

Discover Puracy Laundry Detergent! This detergent offers lasting laundry care for your family. The 16 oz bottle provides up to 64 loads of cleaning power.

It’s plant-powered and non-toxic. This detergent is safe for those with sensitivities.

This detergent is great for all kinds of common messes. It cares for your clothes gently.

Pros Cons
  • Long-lasting power cleans 64 loads from just one bottle.
  • Plant-based formulas keep clothes fresh without harsh scents.
  • Tough on stains like mud and grease with ease.
  • Gently cares for delicate and tough fabrics alike.
  • Safe for kids and pets thanks to expert crafting.
  • Scent might be too faint for some users.
  • Price per load is on the higher side.
  • Drying time could be slightly longer after use.

Perfect For:

Puracy Laundry Detergent is perfect for families who want gentle, natural care for clothes, kids, and pets. It’s ideal for anyone with skin sensitivities seeking fresh, spot-free laundry without harsh chemicals.

Ready to Purchase?

4. Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, Free & Clear Unscented, 1.5 Liter, 100 Loads

Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, Free & Clear Unscented, 1.5 Liter, 100 Loads

Root & Splendor is an ultra concentrated all natural laundry detergent. It cleans your clothes well with just a small amount.

This plant based soap is safe for your family and the earth. It uses a bag-in-box pack to cut down waste. Free & Clear unscented means no scents or dyes.

Pros Cons
  • Ultra concentrated for powerful cleaning with less product.
  • Eco-friendly packaging cuts plastic pollution by 800%.
  • Non-toxic and cruelty-free, safe for all machines.
  • EWG Verified as unscented for sensitive skin.
  • Woman-owned and USA-made for reliable quality.
  • Higher cost per load due to concentration.
  • May lack strong fragrances for fresh scents.
  • Bag-in-box packaging bulky to store.

Perfect For:

This laundry detergent is perfect for families who want safe, eco-friendly laundry options. It also suits people with sensitive skin who seek a cruelty-free, scent-free choice.

Ready to Purchase?

5. Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid – Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1.5 Liter, 100 Loads

Root & Splendor Ultra Concentrated All Natural Laundry Detergent Liquid - Plant Based, Enzymatic Laundry Soap, 2250 Scent, 1.5 Liter, 100 Loads

Root & Splendor is an ultra concentrated laundry detergent. It cleans clothes with just 1 tablespoon per load. This makes washing easy and costs less.

The detergent is eco-friendly and safe for the earth. It comes in a bag-in-box to cut down on waste. Plus, it works in all machines, even HE ones.

The 2250 scent uses natural oils like patchouli and basil. It is made by a woman-owned business in the USA.

Pros Cons
  • Gets clothes ultra clean with tiny amounts.
  • Saves the earth and cuts plastic waste.
  • Safe and kind, no harmful stuff.
  • Smells fresh from natural oils.
  • Made in USA by a caring mom.
  • More expensive than many store-brand detergents.
  • May not handle all tough stains on heavy-duty loads.
  • Box packaging can be bulky and hard to store.

Perfect For:

This ultra concentrated laundry detergent is perfect for families who need strong, plant-based cleaning without harmful chemicals and wasted space. It’s also ideal for people who care about the environment and want safe, eco-friendly care for their clothes.

Ready to Purchase?

6. Puracy Laundry Detergent Refill – Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 48 fl oz, 192 Loads)

Puracy Laundry Detergent Refill - Enzyme-Powered Liquid Laundry Detergent Concentrate, Natural Laundry Detergent Seen on TikTok, Non-Toxic (Fresh Linen, 48 fl oz, 192 Loads)

Puracy Laundry Detergent is a natural choice for clean clothes. It is enzyme-powered and gentle on fabrics. This concentrate gives you 192 loads from one 48 fl oz bottle.

It is made by MDs and PhDs for sensitive skin. You can trust its non-toxic formula.

Fresh Linen scent keeps your laundry fresh and safe. No harsh chemicals harm your skin or the earth. Try Puracy today for better laundry days.

Pros Cons
  • Gentle care for sensitive skin and allergies.
  • Natural ingredients free from harsh chemicals.
  • Enzyme-powered cleaning works on tough stains.
  • Concentrated formula lasts for many washes.
  • Trusted by doctors and scientists.
  • Might not clean tough stains as well as strong detergents.
  • Often costs more than basic laundry products.
  • Has a mild scent that some find too light.

Perfect For:

This natural laundry detergent is perfect for people with sensitive skin or allergies. It gives you clean clothes without any harsh chemicals that could bother your skin.

Ready to Purchase?

7. Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips – Unscented, 48 Loads – Sulfate Free Laundry Detergent With Solid And Liquid Enzymes – Fights Natural Stains and Odor

Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips - Unscented, 48 Loads - Sulfate Free Laundry Detergent With Solid And Liquid Enzymes - Fights Natural Stains and Odor

Say goodbye to tough stains and bad smells with Lazy Coconuts Complete 5 Enzyme Laundry Detergent Strips. This unscented formula uses five enzymes to clean clothes deeply and safely. It fights dirt without harsh chemicals for a fresh feel every time.

Our strips are plastic-free and come in recyclable cardboard packaging. You get 48 loads of easy, pre-measured sheets that dissolve fast in water.

Enjoy a carbon negative clean that helps the planet by offsetting emissions. Switch to this simple, effective detergent today and make laundry fun again.

Pros Cons
  • Powerful enzymes fight tough stains and odors fast.
  • Free of fragrance and harsh chemicals for safe cleaning.
  • Plastic-free strips in recyclable cardboard boxes.
  • Pre-measured strips offer easy, mess-free laundry.
  • Carbon negative washing helps the environment thrive.
  • Strips might not dissolve fully in cold water.
  • Unscented means no fresh smell in your laundry.
  • Higher cost per load compared to liquid detergents.

Perfect For:

This laundry detergent is perfect for busy families and eco-conscious people who want a simple, clean solution without harmful chemicals. It’s also ideal for those with sensitive skin seeking a fragrance-free option that fights stains and odors easily.

Ready to Purchase?

8. Biokleen Laundry Detergent Sheets – Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads

Biokleen Laundry Detergent Sheets - Dye & Fragrance Free, Hypoallergenic, Enzymatic Cleaner, Stain Remover, Bio Active Formula, No Plastic Jug, Unscented, 100 Loads

Biokleen Laundry Detergent Sheets use plant-based enzymes to clean your clothes. They come in recyclable packaging and cut down on plastic waste.

These sheets give you 100 loads from just 50 sheets for great value. They are easy to tear and help you save money.

They dissolve fast in any washing machine. They work well on delicate or dirty items. Grab yours today!

Pros Cons
  • Eco-friendly plant-based clean: gentle on Earth.
  • Superior value: 100 loads from 50 sheets.
  • Spill-free convenience: compact sheets for easy travel.
  • Gentle formula: safe for sensitive skin.
  • Universal power: cleans all fabrics perfectly.
  • Price might feel higher upfront.
  • May dissolve slower in very cold water.
  • Packaging tears easily during use.

Perfect For:

Biokleen Laundry Detergent Sheets are perfect for people who want clean clothes without harmful chemicals, such as those with sensitive skin or allergies.
They also suit eco-friendly families and travelers looking for easy, mess-free laundry that saves money and helps the planet.

Ready to Purchase?

9. Active Wear Laundry Detergent & Soak – Formulated for Sweat and Workout Clothes – Natural Performance Concentrate Enzyme Booster Deodorizer – Powder Wash for Activewear Gym Apparel (90 Loads)

Active Wear Laundry Detergent & Soak - Formulated for Sweat and Workout Clothes - Natural Performance Concentrate Enzyme Booster Deodorizer - Powder Wash for Activewear Gym Apparel (90 Loads)

Active Wear Laundry Detergent is a powder wash made in the USA with natural plant-based enzymes. It works fast to remove sweat smells from your gym clothes.

This soap is special for athletic wear from any brand. It is septic safe and free from harsh chemicals like SLS or phosphates.

Try it on workout shirts and shorts. Save money with 90 loads. Feel clean after every wash.

Pros Cons
  • Removes tough sweat smells from activewear and gym gear fast.
  • Made with natural plant-based enzymes for safe cleaning.
  • Works great on all athletic clothes like shorts and leggings.
  • Save money with concentrated formula for 90 loads!
  • Extends clothes lifespan to keep them lasting longer.
  • Powder form may not dissolve fully in some washing machines
  • Concentrated formula requires careful measuring to avoid waste
  • Plant-based enzymes might work slower than chemical detergents

Perfect For:

This Active Wear Laundry Detergent is perfect for active people who wear gym clothes often. It removes sweat smells from shirts, shorts, leggings, and socks in a natural way.

Ready to Purchase?

10. LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner – 64 Oz (96 Washes) Pet Stain and Odor Eliminator, Enzymatic Detergent by Alpha Tech Pet

LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner - 64 Oz (96 Washes) Pet Stain and Odor Eliminator, Enzymatic Detergent by Alpha Tech Pet

LaundraPet is a premium laundry detergent made for pets. It removes bad smells and stains from pet messes with strong enzymes.
This product uses special enzymes that clean three times better. It works well in cold water to save energy.
Trust LaundraPet from Alpha Tech Pet, a reliable brand with 38 years in pet care. They make eco-friendly products in the USA for safe pet cleaning.

Pros Cons
  • Eliminates tough pet odors and stains quickly.
  • Boosts cleaning power with triple enzymes.
  • Safe for pets, family, and the environment.
  • Works great in high-efficiency washers easily.
  • Saves money with up to ninety-six washes.
  • Price is high for small families.
  • Smell might be strong for some.
  • Heavy bottle hard to carry.

Perfect For:

LaundraPet is perfect for pet owners who need to remove tough stains and odors from poop, urine, or dirt on clothes. It works great for groomers, vets, and kennel workers who want a safe, effective cleaner that saves money on 96 washes.

Ready to Purchase?

Buying Guide

Natural enzymatic detergents clean clothes with plant power. They keep washes fresh without harsh stuff. Users share happy stories about lasting freshness and easy saves.

One user loved how their clothes smelled fresh for days. That meant less washing time. Saving money felt great too.

Users say natural detergents feel clean and safe. They enjoy eco-friendly packs that help the planet. Pet owners praise strong odor fights for messes.

Formulation: Choose plant-based recipes with enzymes for safe cleaning. These break down stains without hurting skin. Pick formulas from trusted brands for peace of mind.

Stain and Odor Removal: Look for products that fight tough spots and smells. Enzymatic types work on everyday dirt and pet messes. They keep clothes fresher longer.

Scent Options: Go for natural smells like herbs or unscented choices. Avoid strong dyes and opt for hypoallergenic picks. This suits families with sensitive noses.

Concentration and Loads: Check how many washes per bottle for good value. Ultra concentrated ones need small amounts per load. That cuts costs and waste over time.

Eco-Friendly Packaging: Prefer bag-in-box or strips that reduce trash. Recyclable options like cardboard save space. This helps the earth with less plastic.

Machine Compatibility: Ensure it works in all washers, even HE models. Cold water use saves energy. Safe for septic systems too.

Safety Features: Seek non-toxic, cruelty-free products for family use. They should suit pets and workout gear. Check for making in the USA by caring teams.

Specific Uses: For pets or active wear, pick strong enzyme boosters. These remove pet pee or sweat smells. They handle clothes and beds well.

Price and Value: Compare load counts to price for smart buys. Refill packs often cost less per wash. Try small sizes first to test.