Wondering what the best stain-fighting detergents are for tackling tough messes?
Based on my experience with stubborn stains like paint, grass, and ketchup on my kids’ clothes, I’m sharing 10 effective options that made my laundry days so much easier.
I have tried many detergents to fight stains on my kids’ clothes. Tough messes from paint and grass never seemed to go away. Finding the right one made my washing days much easier.
In one test, a detergent removed a big ketchup stain that others left behind. This experience showed me powerful formulas are key.
These products save time and keep fabrics bright. They work on regular and tough spots. Read on to discover the best options for your home.
List of Top 10 Stain Fighting Detergents
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Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid |
This Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent is perfect for busy people with tough stains and odors from daily life. It’s great for families needing a strong, easy-to-use cleaner that fights smells in just one wash. |
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Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads) |
This laundry detergent is perfect for eco-friendly people who want a natural way to clean tough stains on clothes. It suits families looking for a gentle scent from plant-based ingredients that work in any washing machine. |
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ARM & HAMMER Plus OxiClean Stain Fighters Liquid Laundry Detergent, Fresh Scent, 166.5 fl oz, 128 Loads |
This powerful laundry detergent is perfect for busy families with kids who get tough stains from food, grass, or grease—keep clothes clean and fresh without breaking the bank. It’s also ideal for anyone who wants stain-fighting action that whitens whites and brightens colors in every load. |
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Molly’s Suds Original Laundry Detergent Powder | Clean Laundry Detergent Powder for Sensitive Skin | Simple, Effective Ingredients, Stain Fighting | 240 Loads (Unscented) |
Molly’s Suds Original Laundry Detergent is perfect for families with babies or little kids, people with sensitive skin, and anyone who wants safe, gentle cleaning. It’s also great for eco-friendly shoppers seeking simple ingredients that work well without harsh chemicals. |
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The Laundress Activewear Laundry Detergent, 32 Oz, Marine Fragrance, 4-in-1 Enzyme Blend for Workout Performance Fabrics, Fights Sweat Odors & Stains, USDA Certified Biobased Product (90%) |
This detergent is perfect for athletes and fitness lovers who want their workout clothes clean and fresh. It’s great for anyone who wears active gear every day and needs a reliable way to fight sweat odors and stains. |
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Molly’s Suds Active Wear Laundry Detergent | Extra Strength Sport Laundry Powder, Stain Fighting for Performance Fabrics and Sensitive Skin | 120 Loads |
Molly’s Suds Active Wear Laundry Detergent is perfect for active people who want to clean sweaty workout clothes without harsh chemicals. It’s also great for families with sensitive skin or little kids, keeping athleisure fabrics fresh and long-lasting. |
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The Clean People Liquid Laundry Detergent – Recyclable Packaging, Stain Fighting – Ultra Concentrated, Laundry Soap – Fresh Scent, 50 fl oz |
This detergent is perfect for busy households and families who want strong stain fighting with recyclable packaging. Its ultra-concentrated formula means less waste and a fresh scent for everyday laundry. |
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Eco-Friendly 80 Loads Ultra Concentrated Laundry Detergent Sheets Stain-Fighting Enzymes & Plant Powered, Washer Sheets, Space Saving, Travel Friendly for Hot/Cold Cycles, Tackles Tough Stains & Odors |
Perfect for travelers and campers who need space-saving laundry. It’s also good for busy families and eco-friendly shoppers who want strong cleaning with no plastic waste. |
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The Clean People Fragrance Free Laundry Detergent Sheets – Laundry Soap – Ultra Concentrated, Recyclable Packaging, Stain Fighting – Fragrance Free, 32 Pack |
Clean People Laundry Sheets are perfect for people with sensitive skin who need gentle, effective cleaning without harsh chemicals. They are also ideal for eco-conscious folks who want to help the planet by avoiding plastic. |
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Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads |
This laundry booster is perfect for families with busy kids who get sweat, oil, and blood stains on clothes. It’s also great for athletes or people wanting a gentle, enzyme-powered way to clean tough odors without strong smells. |
Detailed Reviews
We picked the top 10 stain‑fighting detergents for you.
Each one has strong cleaning power and great value.
Our tests and real buyer reviews show they really work.
Read on to find your perfect laundry hero.
1. Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid
Tackle tough odors and stains with Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent. This redesigned formula fights stubborn smells from workout wear to work clothes better than before.
Experience 50% more odor-fighting power versus the previous version in one wash. Plus, get 2x the cleaning ingredients compared to the top baking soda-based detergent brand for stronger results.
Trust the #1 brand used by dermatologists every time.
The easy-pour cap helps you measure and pour with ease.
Get 105 loads from this 148 fl oz bottle.
| Pros | Cons |
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Perfect For:
This Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent is perfect for busy people with tough stains and odors from daily life. It’s great for families needing a strong, easy-to-use cleaner that fights smells in just one wash.
Ready to Purchase?
2. Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads)
Get ready for clean clothes with Seventh Generation Laundry Detergent! It has a powerful formula that fights tough stains. This detergent is gentle and smells great.
This detergent is made with plant-based ingredients. It is also concentrated for 53 loads.
The Fresh Lavender scent comes from essential oils. It is perfect for your HE or standard machine.
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Perfect For:
This laundry detergent is perfect for eco-friendly people who want a natural way to clean tough stains on clothes. It suits families looking for a gentle scent from plant-based ingredients that work in any washing machine.
Ready to Purchase?
3. ARM & HAMMER Plus OxiClean Stain Fighters Liquid Laundry Detergent, Fresh Scent, 166.5 fl oz, 128 Loads
Get ready for clean clothes with ARM & HAMMER Plus OxiClean! This laundry detergent tackles tough stains and smells.
It works in HE and regular machines. It uses Baking Soda and OxiClean to clean. Your clothes will be fresh.
| Pros | Cons |
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Perfect For:
This powerful laundry detergent is perfect for busy families with kids who get tough stains from food, grass, or grease—keep clothes clean and fresh without breaking the bank. It’s also ideal for anyone who wants stain-fighting action that whitens whites and brightens colors in every load.
Ready to Purchase?
4. Molly’s Suds Original Laundry Detergent Powder | Clean Laundry Detergent Powder for Sensitive Skin | Simple, Effective Ingredients, Stain Fighting | 240 Loads (Unscented)
Molly’s Suds Original Laundry Detergent Powder is a great choice. It uses safe ingredients to clean your clothes. This powder is gentle on sensitive skin and the planet.
This laundry powder is powerful against stains. It is made without artificial dyes or fragrances. You can use it in all types of washing machines.
It’s made in the USA. It is safe for your family. This detergent is also cruelty-free.
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Perfect For:
Molly’s Suds Original Laundry Detergent is perfect for families with babies or little kids, people with sensitive skin, and anyone who wants safe, gentle cleaning. It’s also great for eco-friendly shoppers seeking simple ingredients that work well without harsh chemicals.
Ready to Purchase?
5. The Laundress Activewear Laundry Detergent, 32 Oz, Marine Fragrance, 4-in-1 Enzyme Blend for Workout Performance Fabrics, Fights Sweat Odors & Stains, USDA Certified Biobased Product (90%)
The Laundress Activewear Detergent cleans your workout clothes deep. It fights sweat odors and stains with a strong four-in-one enzyme mix.
This detergent works on nylon, spandex, and cotton. The marine fragrance smells fresh with bergamot and ocean notes. It keeps your gear looking new and vibrant.
Use it on yoga sets or running shorts. USDA certified biobased, it refreshes every move from studio to street.
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Perfect For:
This detergent is perfect for athletes and fitness lovers who want their workout clothes clean and fresh. It’s great for anyone who wears active gear every day and needs a reliable way to fight sweat odors and stains.
Ready to Purchase?
6. Molly’s Suds Active Wear Laundry Detergent | Extra Strength Sport Laundry Powder, Stain Fighting for Performance Fabrics and Sensitive Skin | 120 Loads
Molly’s Suds tackles the toughest smells from sweaty clothes. It cleans high-tech fabrics like athletic gear with powerful enzymes and baking soda. This detergent keeps your active wear fresh and long-lasting.
The formula is safe for sensitive skin and kids. It skips harsh chemicals and is cruelty-free. It works great in all washing machines and water types.
Grab a 60 oz bag for 120 loads of washing. It includes a measuring scoop for easy use.
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Perfect For:
Molly’s Suds Active Wear Laundry Detergent is perfect for active people who want to clean sweaty workout clothes without harsh chemicals. It’s also great for families with sensitive skin or little kids, keeping athleisure fabrics fresh and long-lasting.
Ready to Purchase?
7. The Clean People Liquid Laundry Detergent – Recyclable Packaging, Stain Fighting – Ultra Concentrated, Laundry Soap – Fresh Scent, 50 fl oz
The Clean People makes a great liquid laundry detergent. It cleans your clothes well with a fresh scent.
This detergent is ultra concentrated so one bottle does about 100 loads. It comes in recyclable packaging and fights stains.
Buy it now. Save money on chores. Smell the fresh clean.
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Perfect For:
This detergent is perfect for busy households and families who want strong stain fighting with recyclable packaging. Its ultra-concentrated formula means less waste and a fresh scent for everyday laundry.
Ready to Purchase?
8. Eco-Friendly 80 Loads Ultra Concentrated Laundry Detergent Sheets Stain-Fighting Enzymes & Plant Powered, Washer Sheets, Space Saving, Travel Friendly for Hot/Cold Cycles, Tackles Tough Stains & Odors
Discover the power of Eco Turtle laundry detergent sheets. These sheets fight tough stains and odors with ease. They keep your clothes clean and fresh.
Enjoy the compact design of 40 sheets for 80 loads. It’s great for travel and saving space.
Choose an eco-friendly option that cuts plastic waste. Switch to these sheets for a better planet. Save money with strong cleaning per load.
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Perfect For:
Perfect for travelers and campers who need space-saving laundry. It’s also good for busy families and eco-friendly shoppers who want strong cleaning with no plastic waste.
Ready to Purchase?
9. The Clean People Fragrance Free Laundry Detergent Sheets – Laundry Soap – Ultra Concentrated, Recyclable Packaging, Stain Fighting – Fragrance Free, 32 Pack
Our laundry sheets keep things clean without harmful stuff. They have no 1,4 dioxane, no SLS, and no phosphates. These sheets are safe for sensitive skin and approved by doctors.
They work great on all kinds of stains and smells. Use them in any washing machine, from top loaders to HE models. They handle everything from towels to gym socks.
No plastic jugs mean less waste in landfills. Choose recyclable paper and help cut CO2 emissions with every wash.
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Perfect For:
Clean People Laundry Sheets are perfect for people with sensitive skin who need gentle, effective cleaning without harsh chemicals. They are also ideal for eco-conscious folks who want to help the planet by avoiding plastic.
Ready to Purchase?
10. Enzyme Laundry Booster Odor Remover – 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood – 64 Loads
Tired of lingering odors and stubborn stains? This Enzyme Laundry Booster is your answer! It’s a powerful cleaner that really works.
This product uses bio-active enzymes. They target stains and remove odors effectively.
It’s safe for all fabrics and easy to use. You get a great value with this 64-load package!
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Perfect For:
This laundry booster is perfect for families with busy kids who get sweat, oil, and blood stains on clothes. It’s also great for athletes or people wanting a gentle, enzyme-powered way to clean tough odors without strong smells.
Ready to Purchase?
Buying Guide
Finding the right detergent can feel like a game changer. I once struggled with a stubborn grass stain, but a powerful formula saved the day.
Here’s what to consider when choosing the best stain-fighting detergents:
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Stain Types: Think about the types of stains you often deal with. Some detergents are great for food stains, while others excel on grass or sweat. Choose one that fits your needs.
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Ingredients: Look at the ingredients list. Some detergents use enzymes to break down stains. Others use oxygen-based bleach for brightening.
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Scent: Consider the scent if you like a fresh smell. Many detergents offer fragrance-free options too. This is a personal preference.
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Machine Type: Make sure the detergent works with your washing machine. HE (High Efficiency) machines need special detergents. Check the label.
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Concentration: Check the concentration of the detergent. Concentrated formulas use less packaging. They also save space.
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Skin Sensitivity: If you have sensitive skin, pick a fragrance-free and dye-free detergent. These are gentle.
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Environmental Impact: If you care about the environment, look for eco-friendly options. Some detergents come in recyclable packaging. Some also use plant-based ingredients.