10 Best Stain-Fighting Laundry Detergents: Your Ultimate Guide

What are the best stain-fighting laundry detergents?
I vividly remember getting coffee stains on my favorite shirt and using a top stain-fighting detergent that made them disappear in just one wash, and now I’m sharing my guide to help you find the perfect option for clean clothes.

Finding the right laundry detergent can make your clothes look new again. Many detergents claim to fight stains, but choosing the best one takes time.

I once struggled with juice stains on my favorite shirt. After trying a top stain-fighting detergent, the spot vanished in one wash. Trust me, my guide will help you pick the perfect option for clean clothes.

List of Top 10 Stain-Fighting Laundry Detergents

Image Title Best For Price
Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid

This laundry detergent is perfect for busy families with kids who play sports or have active jobs. It’s also great for anyone who wants to clean tough stains and smells like sweat from clothes in just one wash.

ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

This detergent is perfect for busy families and active people who deal with tough odors, stubborn stains, and sweaty clothes every day. It gives your laundry a fresh, clean burst that lasts, making it easy to feel good in what you wear.

OxiClean White Revive Laundry Whitener and Stain Remover Liquid, 50 fl oz OxiClean White Revive Laundry Whitener and Stain Remover Liquid, 50 fl oz

Are your whites looking dull? Then OxiClean White Revive is for you! If you want brighter whites without bleach, this is your new laundry secret.

Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads) Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads)

This detergent is perfect for busy homes. It fights tough stains and is made with plant-based ingredients.

ARM & HAMMER Plus OxiClean with Odor Blasters 5-in-1 Laundry Detergent Power Paks, Laundry Odor Remover, Eliminates Odors, Attacks Stains, Fresh Burst Scent, 42 Count​ ARM & HAMMER Plus OxiClean with Odor Blasters 5-in-1 Laundry Detergent Power Paks, Laundry Odor Remover, Eliminates Odors, Attacks Stains, Fresh Burst Scent, 42 Count​

This laundry detergent is perfect for busy families who need fast, mess-free cleaning for tough stains and bad smells. It’s also great for anyone wanting easy-to-use packs that whiten clothes and add fresh scent without extra work.

Tide Liquid Laundry Detergent, Original Scent, 125 fl oz, 100 Loads, Boosted Clean Even in Cold Water with Concentrated Washing Soap Tide Liquid Laundry Detergent, Original Scent, 125 fl oz, 100 Loads, Boosted Clean Even in Cold Water with Concentrated Washing Soap

Tide Liquid Laundry Detergent is perfect for anyone who wants super-clean and fresh-smelling clothes. It’s strong on stains, easy to use, and works in all washing machines.

ARM & HAMMER Liquid Laundry Detergent, Clean Burst Fresh, 170 fl oz, 170 Loads ARM & HAMMER Liquid Laundry Detergent, Clean Burst Fresh, 170 fl oz, 170 Loads

This ARM & HAMMER laundry soap cleans 170 loads with fresh Clean Burst smell to fight stains and tough odors. It is perfect for big families with kids, team uniforms, towels, and sheets that need deep clean without spending too much.

Era 2X Ultra Active Stainfighter Formula Regular Liquid Laundry Detergent 154 lf oz 107 Loads Era 2X Ultra Active Stainfighter Formula Regular Liquid Laundry Detergent 154 lf oz 107 Loads

Tired of stubborn stains? Era 2X Ultra Active Stainfighter is perfect for you. It’s a powerful and reliable laundry detergent that gets clothes clean.

Tide Ultra Oxi Boost Liquid Laundry Detergent, 92 fl oz, 65 Loads, Advanced Stain Remover, Laundry Detergent Liquid with Extra Oxi Power Tide Ultra Oxi Boost Liquid Laundry Detergent, 92 fl oz, 65 Loads, Advanced Stain Remover, Laundry Detergent Liquid with Extra Oxi Power

Tide Ultra Oxi Boost is perfect for busy families and active households dealing with tough stains like dirt, grass, or food. You can skip pre-treating and still get powerful cleaning in every wash.

ARM & HAMMER Plus OxiClean Fresh Scent, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz ARM & HAMMER Plus OxiClean Fresh Scent, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

Tired of stubborn stains and lingering odors? This laundry detergent is your secret weapon. It is perfect for anyone who wants clean, fresh-smelling clothes without breaking the bank.

Detailed Reviews

We tested the top ten stain‑fighting detergents.
Our expert and customer scores reveal the best.
Find the perfect pick for fresh, clean clothes.

1. Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid

Tide Ultra Odor Defense Plus Oxi Liquid Laundry Detergent, 148 fl oz, 105 Loads, Advanced Odor and Stain Fighting Laundry Detergent Liquid

This new Tide formula tackles tough odors and stains. It gives you 50% more odor-fighting power.

It removes stubborn smells in one wash. It has twice the cleaning ingredients. This works better than other brands.

The bottle has an easy-pour cap. It is a trusted formula. This big bottle does 105 loads.

Pros Cons
  • Fights tough odors and stains in one wash.
  • Has 50% more odor-fighting power.
  • Contains 2x the cleaning ingredients.
  • Easy-pour cap makes using it simple.
  • Costs more than other brands.
  • Large bottle is heavy to carry.
  • Some may find scent is strong.

Perfect For:

This laundry detergent is perfect for busy families with kids who play sports or have active jobs. It’s also great for anyone who wants to clean tough stains and smells like sweat from clothes in just one wash.

Ready to Purchase?

2. ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

This ARM & HAMMER Plus OxiClean detergent is tough on stains. It fights bad odors like sweat and musty towels. It leaves your clothes with a fresh burst scent.

It deeply cleans your laundry with trusted baking soda. This liquid laundry detergent works in all machines. One bottle cleans seventy-seven loads.

Clean deep, don’t spend deep. It is a trusted household staple for your family.

Pros Cons
  • Fights tough odors and body sweat effectively.
  • Blasts away stubborn stains from grass and grease.
  • Delivers lasting freshness with Fresh Burst scent.
  • Deep cleans clothes using trusted baking soda.
  • Offers great value for 77 loads of laundry.
  • High cost per load hurts wallet.
  • Strong scent might bother sensitive noses.
  • Liquid spills make mess in storage.

Perfect For:

This detergent is perfect for busy families and active people who deal with tough odors, stubborn stains, and sweaty clothes every day. It gives your laundry a fresh, clean burst that lasts, making it easy to feel good in what you wear.

Ready to Purchase?

3. OxiClean White Revive Laundry Whitener and Stain Remover Liquid, 50 fl oz

OxiClean White Revive Laundry Whitener and Stain Remover Liquid, 50 fl oz

Bring back the shine to your white clothes. OxiClean White Revive is a chlorine-free booster that whitens whites 40% better than chlorine bleach.

No more dull towels or stained shirts. Mix it with water for a presoak, add it to your washer, or pretreat spots on your laundry.

It works on t-shirts, sheets, socks, and more. Your whites will look fresh again. Try it today.

Pros Cons
  • Whitens whites brilliantly, no chlorine needed.
  • Stain remover tackles tough spots easily.
  • Color-safe formula protects all fabrics.
  • Easy to use as boost or presoak.
  • May not fully remove very stubborn stains.
  • Requires following directions for best results.
  • Only whitens whites; not for colors.

Perfect For:

Are your whites looking dull? Then OxiClean White Revive is for you! If you want brighter whites without bleach, this is your new laundry secret.

Ready to Purchase?

4. Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads)

Seventh Generation Concentrated Laundry Detergent, Stain Fighting Formula, Fresh Lavender scent, 40 oz (53 Loads)

Get tough stains out of your clothes with this powerful detergent. It smells fresh with lavender scent from real plants.

Wash 53 loads from one bottle in any machine. This cleaner is 96% plant-based and certified by the USDA.

Buy now to enjoy clean clothes. The triple-enzyme formula works great. Save time and money too.

Pros Cons
  • Powerful formula fights tough stains easily.
  • Smells fresh with lavender from plants.
  • Concentrated bottle washes 53 loads.
  • 96% plant-based and good for Earth.
  • Scent may be too strong for some users.
  • Plant-based may not work on all stains.
  • Only 53 loads per bottle.

Perfect For:

This detergent is perfect for busy homes. It fights tough stains and is made with plant-based ingredients.

Ready to Purchase?

5. ARM & HAMMER Plus OxiClean with Odor Blasters 5-in-1 Laundry Detergent Power Paks, Laundry Odor Remover, Eliminates Odors, Attacks Stains, Fresh Burst Scent, 42 Count​

ARM & HAMMER Plus OxiClean with Odor Blasters 5-in-1 Laundry Detergent Power Paks, Laundry Odor Remover, Eliminates Odors, Attacks Stains, Fresh Burst Scent, 42 Count​

Tired of smelly clothes? ARM & HAMMER Plus OxiClean is here to help. These Power Paks make laundry easy. Get ready for a fresh, clean scent!

These 5-in-1 paks are super powerful. They eliminate tough odors and attack stains. Whites get whiter and colors get brighter.

It’s so simple to use. Just drop and go!

Pros Cons
  • Powerful 5-in-1 cleaning in one easy step.
  • Eliminates tough odors and attacks stubborn stains.
  • No mess with convenient pre-measured Power Paks.
  • Leaves laundry smelling fresh and wonderfully clean.
  • Pre-measured: Can’t adjust the dose for small loads.
  • May not dissolve well in very cold water.

Perfect For:

This laundry detergent is perfect for busy families who need fast, mess-free cleaning for tough stains and bad smells. It’s also great for anyone wanting easy-to-use packs that whiten clothes and add fresh scent without extra work.

Ready to Purchase?

6. Tide Liquid Laundry Detergent, Original Scent, 125 fl oz, 100 Loads, Boosted Clean Even in Cold Water with Concentrated Washing Soap

Tide Liquid Laundry Detergent, Original Scent, 125 fl oz, 100 Loads, Boosted Clean Even in Cold Water with Concentrated Washing Soap

Tide Liquid Laundry Detergent gives you a 6X boosted clean. It works even in cold water.

It has a concentrated formula. This means more cleaning power. It fights tough stains.

It leaves clothes with long-lasting freshness. It is easy to use. One jug does 100 loads.

Pros Cons
  • 6X boosted clean for superior results.
  • Tough on stains, fights grease easily.
  • Concentrated formula saves space and dose.
  • Long-lasting freshness keeps clothes smelling great.
  • Easy to use in all machines and cycles.
  • Strong scent might be too overpowering.
  • Could cause skin irritation for some.
  • Expensive compared to basic brands.

Perfect For:

Tide Liquid Laundry Detergent is perfect for anyone who wants super-clean and fresh-smelling clothes. It’s strong on stains, easy to use, and works in all washing machines.

Ready to Purchase?

7. ARM & HAMMER Liquid Laundry Detergent, Clean Burst Fresh, 170 fl oz, 170 Loads

ARM & HAMMER Liquid Laundry Detergent, Clean Burst Fresh, 170 fl oz, 170 Loads

This detergent deeply cleans your clothes. It uses 2X powerful stain fighters. You get a fresh, clean burst scent.

It works in all washing machines. The formula is low-sudsing and clean-rinsing.

One bottle washes 170 medium loads. It removes tough dirt and odors. Trust ARM & HAMMER Baking Soda.

Pros Cons
  • Cleans up to 170 loads powerfully.
  • Fights tough stains with 2X strength.
  • Blended with pure baking soda for deep cleaning.
  • Leaves clothes with a fresh, clean scent.
  • Low-sudsing formula works great in HE machines.
  • Fragrance may be too strong for some.
  • Large bottle can be hard to pour.
  • Not very eco-friendly.

Perfect For:

This ARM & HAMMER laundry soap cleans 170 loads with fresh Clean Burst smell to fight stains and tough odors. It is perfect for big families with kids, team uniforms, towels, and sheets that need deep clean without spending too much.

Ready to Purchase?

8. Era 2X Ultra Active Stainfighter Formula Regular Liquid Laundry Detergent 154 lf oz 107 Loads

Era 2X Ultra Active Stainfighter Formula Regular Liquid Laundry Detergent 154 lf oz 107 Loads

Tired of stubborn stains ruining your clothes? Era 2X Ultra Active Stainfighter is here to help. This liquid laundry detergent works hard, so you don’t have to. Get ready for clean and fresh clothes!

This bottle contains 154 ounces and cleans up to 107 loads. Era makes laundry simple!

Pros Cons
  • Fights tough stains fast and easy.
  • Gives you 107 loads of clean power.
  • Trusted Era brand from P&G.
  • Simple liquid form for quick pouring.
  • Keeps clothes fresh and bright daily.
  • Very heavy bottle to carry and pour.
  • Limited scent options for personal preference.
  • Big container needs a lot of storage space.

Perfect For:

Tired of stubborn stains? Era 2X Ultra Active Stainfighter is perfect for you. It’s a powerful and reliable laundry detergent that gets clothes clean.

Ready to Purchase?

9. Tide Ultra Oxi Boost Liquid Laundry Detergent, 92 fl oz, 65 Loads, Advanced Stain Remover, Laundry Detergent Liquid with Extra Oxi Power

Tide Ultra Oxi Boost Liquid Laundry Detergent, 92 fl oz, 65 Loads, Advanced Stain Remover, Laundry Detergent Liquid with Extra Oxi Power

Tide Ultra Oxi Boost is the most powerful liquid laundry detergent. It fights tough stains with extra Oxi power.

Skip pre-treating stains. This detergent wipes them out in every wash.

Get 2x the cleaning power versus the top baking soda brand. The clear easy-pour cap makes measuring simple. Trust the #1 brand from dermatologists for clean clothes.

Pros Cons
  • Packed with extra Oxi for super strong cleaning.
  • Skip pre-treating stains and save time.
  • Get 2x more ingredients than top rivals.
  • Easy-pour cap makes it simple to use.
  • Trusted formula from the #1 brand dermatologists pick.
  • Large bottle can be heavy to handle.
  • Strong formula might harm delicate fabrics.
  • Higher price than regular detergents.

Perfect For:

Tide Ultra Oxi Boost is perfect for busy families and active households dealing with tough stains like dirt, grass, or food. You can skip pre-treating and still get powerful cleaning in every wash.

Ready to Purchase?

10. ARM & HAMMER Plus OxiClean Fresh Scent, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

ARM & HAMMER Plus OxiClean Fresh Scent, 77 Loads Liquid Laundry Detergent, 100.5 Fl oz

ARM & HAMMER Plus OxiClean Fresh Scent Liquid Laundry Detergent cleans 77 loads with one 100.5 fl oz bottle. It fights stains and odors while whitening whites and brightening colors.

This HE detergent uses Baking Soda and OxiClean to deep clean your clothes. It boosts freshness that lasts all day.

Remove over 101 stains like food and grass. Works in standard and HE washers. Get clean clothes without deep spending.

Pros Cons
  • Powerful clean with OxiClean and Baking Soda!
  • Fights stains, odors, and brightens colors easily..
  • Saves money with 77 loads in one bottle!
  • Works in all washers, HE or standard.
  • Trusted brand; clean that won’t break the bank!
  • Scent may be too strong for some
  • Large bottle can be hard to store
  • Not great for very tough stains

Perfect For:

Tired of stubborn stains and lingering odors? This laundry detergent is your secret weapon. It is perfect for anyone who wants clean, fresh-smelling clothes without breaking the bank.

Ready to Purchase?

Buying Guide

Finding the best stain-fighting laundry detergent can bring back your clothes like new. Many brands promise to remove stubborn spots, but picking the right one needs care. This guide shows you ready options for clean laundry every day.

I recall spilling juice on my best shirt one evening. I tried a strong stain-fighting detergent, and it made the mark go away after just one wash. That success made me trust these products for tough messes.

  • Stain-Fighting Power: Look for detergents with strong ingredients to tackle tough stains like juice or grass. Choose ones with OxiClean for extra lift on spots. Test it on small areas first to see results.

  • Odor Removal: Pick detergents that fight bad smells from sweat or musty towels. Brands with baking soda often work well to keep clothes fresh. Odor-free options help if you have allergies.

  • Detergent Type: Think about liquid, pods, or powder based on your washer type. Liquids pour easy and rinse out clean. Pods dissolve fast without mess, saving time.

  • Scent Options: Select a fresh scent that fits your taste, like lavender or fresh burst. Mild scents last longer and do not bother the nose. No-scent choices keep clothes neutral.

  • Load Capacity: Check how many loads the bottle covers to match your needs. Bigger bottles cost less per wash. Watch for 100 loads or more for busy homes.

  • Effectiveness on Whites and Colors: For white clothes, get whiteners that brighten without harm. Color-safe options keep bright shades from fading. He detergents work fine in new machines.

  • Eco-Friendliness: Go for plant-based or biodegradable formulas if you care about the earth. Brands with USDA seals show clean ingredients. These save water and energy too.

  • Price and Value: Compare costs per load to find deals. Cheap ones may work for light stains, but premium give better results. Look for bundles to save money on bulk buys.

  • Ease of Use: Choose detergents with easy-pour caps or simple dosing. Pre-treat sprays help on tough spots. Read labels for washing machine rules.

  • Brand Reputation: Trust known brands like Tide or Arm & Hammer for safe, tested products. Read reviews from users for real feedback. Dermatologist-tested ones avoid skin issues.